Figure 5.

DNA Methylation Levels at cg04827223 and Percentage of T2D Cases by Genotype Classes for rs1552224 in SJLIFE Survivor Subgroups with Differential Exposures to Abdominal or Pelvic Radiation Therapy

No radiation therapy (RT) dose was defined as 0 Gy (column A), low-to-moderate RT dose was defined by >0 to <20 Gy (column B), and high dose was defined by ≥20 Gy (column C). The upper panels show the observed methylation level relationships with the SNP at the cg04827223 CpG site in the SJLIFE subset with methylome and genotype data (n = 236); boxes represent the median and interquartile range (IQR), with whiskers extending from the first or third quartile to 1.5 times the IQR. Methylation level trend by allele dose is shown with median regression lines. Genotype frequencies in this SJLIFE subset were as follows: 1.8% (C/C), 30.8% (C/A), and 67.4% (A/A). The lower panels show the percentage (%) of T2D cases by genotype in SJLIFE survivors in the main analysis (n = 2,112), with the following genotype frequencies: 1.9% (C/C), 26.9% (C/A), and 71.2% (A/A).