FIGURE 2.

Longitudinal changes in the total composite score in Hyp and WT mice. (A) A total composite score was established following the scoring grid (Table 1) for each mouse at each time point (M3, 6, 9, 12). Enthesophytes, erosions and ossifications were observed in each Hyp mouse and no abnormalities were observed in controls. These lesions were already present at M3, the composite score increasing continuously over time. (B) Scores of enthesopathies, erosions, ossifications, and narrowing of joint established following the scoring grid (Table 1) for each Hyp mouse at M12. No spinal enthesophytes were observed. The pattern of lesions differed between Hyp mice.