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. 2020 Sep 22;8:854. doi: 10.3389/fcell.2020.00854

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Copyright © 2020 Faraji-Bellée, Cauliez, Salmon, Fogel, Zhukouskaya, Benoit, Schinke, Roux, Linglart, Miceli-Richard, Chaussain, Briot and Bardet.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Features of sacroiliac joint of Hyp and WT mice. (A) Micro-CT analysis showed bone erosion of the sacroiliac joint in Hyp mice which appears at early stages and progressed up to M12 (representative micro-CT sections from Hyp#2 mouse) (scale bars, 500 μm). (B) Masson’s trichrome staining displayed that sacroiliac bone of Hyp mice presented a large amount of collagen matrix compared to WT mice. Von Kossa staining showed a weak mineralization (in dark) of the Hyp collagen matrix revealing an enlarged osteoid characteristic of features of osteomalacia bone. Safranin O staining revealed high wear of cartilage at M3 in Hyp mice (scale bars, 200 μm).