Figure 3.

Hierarchical Clustering Analysis

HNF1A missense alleles characterized at Oxford (A) and Bergen (B). WARD minimum variance method was used and analysis performed using orthogonally transformed functional data from PC1-PC4 (>85% explained variance) from Oxford dataset and PC1-PC5 (>85% explained variance) form Bergen dataset. To optimize visualization of the function phenotype gradient, some branches were rotated. The numbers of the y axes of (A) and (B) refer to clustering height calculated as by Ward's criterion (total within-cluster variance).