Figure 3.

Manhattan Plots of BGW-TWAS Results of Neurofibrillary Tangle Density and $\text{β}$-Amyloid Load

Here, -log10(p values) by BGW-TWAS were plotted and Red lines denote genome-wide significant threshold (2.5 × 10⁻⁶) for gene-based association studies. ZC3H12B was found to be significantly associated with neurofibrillary tangle density (A). KCTD12 was found to be significantly associated with and $\mathbf{\beta }$-amyloid load (B).