Table 1.

Significant Risk Genes Identified by BGW-TWAS using Individual-Level GWAS Data from ROS/MAP and MCADGS Cohorts

Gene	CHR	Position	Train R2	p Value	Effect Size (SD)	Phenotype
ZC3H12B	X	64,708,614	0.24	5.42 × 10−13	0.265 (0.037)	AD
ZC3H12B	X	64,708,614	0.24	9.59 × 10−7	0.142 (0.029)	global AD pathology
ZC3H12B	X	64,708,614	0.24	1.89 × 10−6	0.138 (0.029)	tangles
KCTD12	13	77,454,311	0.09	3.44 × 10−8	0.143 (0.026)	$\beta$-amyloid