Skip to main content
. 2020 Sep 21;107(4):714–726. doi: 10.1016/j.ajhg.2020.08.022

Table 4.

Average Sums of Posterior Probabilities of Having Non-zero eQTL Effect Sizes that Are Stratified Based on Gene Expression Heritability (Either True Simulated Heritability in Simulation Studies or the Range of Train R2 of the Fitted BVSR Models with ROS/MAP Data

Gene Expression Heritability Sum of Posterior Probabilities
Whole Genome cis-Region trans-Region
5 True Causal eQTL

0.05 0.79 0.46 0.33
0.1 2.28 1.13 1.15
0.2 3.72 1.44 2.28
0.5 4.91 1.56 3.35

22 True Causal eQTL

0.05 0.05 0.02 0.03
0.1 0.21 0.11 0.10
0.2 1.43 0.87 0.56
0.5 6.46 3.89 2.57

ROS/MAP

(0, 0.05) 1,504 genes 6.63 0.60 6.23
(0.05, 0.1) 1,964 genes 1.45 0.13 1.32
(0.1, 0.25) 6,617 genes 2.00 0.17 1.83
(0.25, 0.5) 3,224 genes 2.66 0.22 2.44
(0.5, 1) 474 genes 3.04 0.31 2.73

The simulation scenarios presented here are those with 2 of 5 and 11 of 22 true causal eQTL from the cis-regions.