. 2020 Oct 5;180(12):1621–1629. doi: 10.1001/jamainternmed.2020.4325

Table 2. Absolute Risk, Risk Reduction, and Number Needed to Treat (NNT).

Outcome	Adjusted risk, mean (SE)		Risk reduction, early NIT adjusted risk − control adjusted risk, mean (95% CI)^a	P value	NNT absolute risk reduction
Outcome	No early NIT (n = 62 876)	Early NIT (n = 16 164)		P value	NNT absolute risk reduction
Death or MI	0.005 (0.0008)	0.0008 (0.0004)	−0.004 (−0.006 to −0.003)^b	<.001	1/0.004 = 250^b
Death	0.0019 (0.0003)	0.00013 (0.00005)	−0.002 (−0.002 to −0.001)^b	<.001	1/0.002 = 500^b
Acute MI	0.003 (0.0009)	0.0007 (0.0003)	−0.003 (−0.005 to −0.001)^b	.004	1/0.003 = 333^b
Coronary revascularization	0.004 (0.002)	0.002 (0.002)	−0.002 (−0.006 to 0.003)	.45	NA^c
MACE	0.006 (0.001)	0.0008 (0.0003)	−0.005 (−0.007 to −0.003)^b	<.001	1/0.005 = 200^b

Abbreviations: MACE, major adverse cardiovascular events; MI, myocardial infarction; NA, not applicable; NIT, noninvasive cardiac testing.

^{^a}

All models adjusted for age, sex, race, smoking, body mass index (calculated as weight in kilograms divided by height in meters squared), self and family history of coronary artery disease, initial troponin, antidiabetic medication, anticoagulant medication, antihyperlipidemia medication, antihypertension medication, and Elixhauser comorbidities.

^{^b}

Statistically significant difference.

^{^c}

Differences in event rates are not statistically significant at α = 0.05, and the 95% CI contains zero.