Table 2. Association of Assignment to the Health Guidance Intervention With Health Outcomes Using Fuzzy Regression Discontinuity Design^a.

Outcome
	Main		Long term
	1 y after screening (2015) (n = 39 161)	P value	2 y after screening (2016) (n = 34 293)	P value	3 y after screening (2017) (n = 31 400)	P value	4 y after screening (2018) (n = 28 975)	P value
Change in weight
Body weight, kg	−0.29 (−0.50 to −0.08)	.005	−0.33 (−0.61 to −0.05)	.02	−0.28 (−0.58 to 0.08)	.13	−0.06 (−0.38 to 0.37)	.96
BMIb	−0.10 (−0.17 to −0.03)	.008	−0.10 (−0.20 to −0.01)	.03	−0.10 (−0.20 to 0.02)	.12	−0.01 (−0.12 to 0.14)	.86
Waist circumference, cm	−0.34 (−0.59 to −0.04)	.02	−0.33 (−0.64 to 0.04)	.09	−0.44 (−0.84 to −0.06)	.03	−0.35 (−0.78 to 0.09)	.12
Change in cardiovascular risk factors
Systolic blood pressure, mm Hg	0.28 (−0.53 to 1.47)	.36	0.26 (−0.97 to 1.66)	.61	−0.36 (−1.83 to 0.90)	.51	−1.16 (−2.76 to 0.17)	.08
Diastolic blood pressure, mm Hg	−0.54 (−1.33 to 0.04)	.07	−0.004 (−0.90 to 0.92)	.98	−0.18 (−1.14 to 0.73)	.67	−0.87 (−2.00 to 0.06)	.06
Hemoglobin A1c, %	−0.01 (−0.04 to 0.03)	.74	0.01 (−0.02 to 0.06)	.30	0 (−0.04 to 0.04)	.92	0.02 (−0.02 to 0.07)	.21
LDL cholesterol, mg/dL	0.42 (−1.38 to 2.33)	.62	−0.83 (−3.02 to 1.18)	.39	−0.56 (−3.04 to 1.60)	.54	0.07 (−2.25 to 2.77)	.84

Abbreviations: BMI, body mass index; LDL, low-density lipoprotein.

^a We used the bandwidth of regression discontinuity design of 6 cm from the threshold of waist circumference. Analyses were adjusted for age, lifestyle variables (current smoking, alcohol use, exercise habits), systolic blood pressure, diastolic blood pressure, hemoglobin A_1c level, LDL cholesterol level, and drug use (antihypertensive drugs, antidiabetic drugs, antihyperlipidemic drugs).

^b Calculated as weight in kilograms divided by height in meters squared.

SI conversion factors: To convert LDL cholesterol to mmol/L, multiply by 0.0259. To convert percentage of total hemoglobin to proportion of total hemoglobin, multiply by 0.01.