Table 1. Initial PfPKG SAR.
Cpd | % Inh@10 μM | IC50 (nM) |
8 | 23 | ND |
9a | 1000 | |
9b | 60 | ND |
11a | 1000 | |
11b | 1400 | |
11c | 850 | |
13a | 2100 | |
13b | 210 | |
13c | 2800 |
Cpd | % Inh@10 μM | IC50 (nM) |
8 | 23 | ND |
9a | 1000 | |
9b | 60 | ND |
11a | 1000 | |
11b | 1400 | |
11c | 850 | |
13a | 2100 | |
13b | 210 | |
13c | 2800 |