Table 2. PfPKG inhibition-pyrrolidine derivatives.
Cpd | % Inh@10 μM | IC50 (nM) | Cpd | % Inh@10 μM | IC50 (nM) |
16a | 900 | 16k | 38 | ||
16b | 360 | 16l | 10 | ||
16c | 660 | 16m | 620 | ||
16d | 13 | 17a | 5 | ND | |
16e | 15 | 17b | 5 | ND | |
16f | 74 | 17c | 40 | ND | |
16g | 25 | 19a | 2600 | ||
16h | 120 | 19b | 60 | ND | |
16i | 97 | 19c | 46 | ND | |
16j | 47 | 19d | 75 | ND |