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. Author manuscript; available in PMC: 2020 Nov 27.
Published in final edited form as: Nature. 2020 May 27;583(7814):122–126. doi: 10.1038/s41586-020-2337-2

Figure 2 -. in vivo manipulation of the hepatic cytosolic NADH/NAD+ ratio alters hepatic and circulating αHB.

Figure 2 -

(a) Experiment outline. Effects of combination of hepatic LbNOX or luciferase expression and alcohol on (b) hepatic NADH/NAD+, (c) hepatic αHB (d) plasma αHB, (e) plasma lactate/pyruvate, (f) plasma βHB/AcAc. Data are mean ± s.e.m from n=8–10 mice per group. p values were determined using one-way ANOVA with post-hoc Tukey’s HSD test. n.s. is p=0.90.