Figure 2.

HLA-B^∗55:01 Allele Association with Self-Reported Penicillin Allergy

The odds ratios (dots) and 95% confidence intervals (CI, horizontal lines) for the association of the HLA allele with penicillin allergy are presented. The plot is annotated with p values and case-control numbers. Color coding indicates the results for discovery cohorts UKBB (black), EstBB (blue), and BioVU (purple) and replication results of the HLA-B^∗55:01 allele in the 23andMe research cohort (green). Results of the meta-analysis of all four cohorts is indicated with a diamond (red). Self-reported penicillin allergy is defined as ICD10 code Z88.0 (UKBB), reported drug allergy labels from the allergy section of the EHR (BioVU), reported allergy to drugs in ATC J01C^∗ class (EstBB), or reported allergy to penicillin (23andMe).