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. Author manuscript; available in PMC: 2020 Oct 6.
Published in final edited form as: Am J Med Genet C Semin Med Genet. 2016 Nov 8;172(4):349–366. doi: 10.1002/ajmg.c.31534

Figure 2. Vector delivery.

Figure 2.

Schematic illustration of subretinal and intravitreal delivery of therapeutic gene-containing vectors. Vector delivery can be achieved by subretinal injection of the viral vector, which involves the formation of a transient retinal detachment that spontaneously resolves. Intravitreal injection is less invasive and produces fewer iatrogenic complications, but may deliver therapeutic genes less efficiently. ON, optic nerve; RPE, retinal pigment epithelium.