Table 1. NOT1 signature domains in THK1 and THKL1 proteins.
| InterPro Domain | Motif Name | Function | THK1 Residues | THKL1 Residues |
|---|---|---|---|---|
| IPR032194 | HEAT repeat | NOT10 binding (Basquin et al., 2012; Bawankar et al., 2013) | 473–617 | 470–615 |
| IPR032193 | TTP-binding domain | CAF1 binding (Fabian et al., 2013) | 653–820 | 652–826 |
| IPR032191 | MIF4G | CAF1 binding (Petit et al., 2012) | 975–1,194 | 982–1,201 |
| IPR024557 | DUF3819 | CAF40 binding (Mathys et al., 2014) | 1,325–1,465 | 1,332–1,453 |
| IPR007196 | NOT1 C terminus | NOT2/NOT5 binding (Bhaskar et al., 2013) | 2,062–2,435 | 2,149–2,522 |
| NOT4 binding (Bhaskar et al., 2015) |