Table 3.
Risk factor assessment for early inflammatory injury
| Covariate | Microvascular Inflammation ≥2 | Tubulointerstitial Inflammation ≥2 | Acute Rejection |
|---|---|---|---|
| HR (95% CI) | HR (95% CI) | HR (95% CI) | |
| No. of events | n=86 | n=146 | n=166 |
| Donor age, per yr | 1.01 (0.99 to 1.03) | 1.01 (0.99 to 1.02) | 1.01 (0.99 to 1.02) |
| Living donor versus donation after brain death | 0.51 (0.15 to 1.70) | 0.51 (0.19 to 1.32) | 0.43 (0.17 to 1.10) |
| Donation after circulatory death versus donation after brain death | 1.00 (0.30 to 3.29) | 0.97 (0.43 to 2.16) | 1.16 (0.56 to 2.41) |
| Cold ischemia time, h | 0.98 (0.94 to 1.04) | 0.99 (0.95 to 1.03) | 0.99 (0.96 to 1.03) |
| Asystolic ischemia time, min | 0.99 (0.93 to 1.06) | 1.01 (0.97 to 1.05) | 1.00 (0.97 to 1.04) |
| Anastomosis time, min | 1.01 (0.98 to 1.04) | 1.00 (0.97 to 1.02) | 1.00 (0.98 to 1.02) |
| HLA A-B-DR mismatches, per mismatch | 1.15 (0.96 to 1.38) | 1.38 (1.20 to 1.60) | 1.34 (1.17 to 1.53) |
| Pretransplant HLA DSAs, present versus absent | 6.94 (4.04 to 11.94) | 3.02 (1.87 to 4.89) | 3.97 (2.61 to 6.05) |
Risk factors assessed by multivariable Cox proportional hazard analysis (n=291 biopsies). HR, hazard ratio; 95% CI, 95% confidence interval; DSAs, donor-specific antibodies. Adjusted for recipient age, recipient body mass index at transplantation, recipient and donor sex, pretransplant diabetes mellitus, repeat transplantation, immunosuppressive regimen at time of transplantation, and induction therapy.