Table 4.
Risk assessment of early events and baseline characteristics on death-censored graft failure
| Covariate | Hazard Ratio (95% CI) |
|---|---|
| No. of events/no. of transplants | 148/976 |
| Donor age, per yr | 1.01 (1.00 to 1.02) |
| Donor type | |
| Living donor versus donation after brain death | 0.36 (0.13 to 1.05) |
| Donation after circulatory death versus donation after brain death | 0.49 (0.19 to 1.27) |
| Cold ischemia time, h | 0.99 (0.96 to 1.03) |
| Asystolic ischemia time, min | 1.02 (0.98 to 1.07) |
| Anastomosis time, min | 1.00 (0.98 to 1.02) |
| HLA A-B-DR mismatches, per mismatch | 1.20 (1.04 to 1.38) |
| Pretransplant HLA DSAs, present versus absent | 1.88 (1.16 to 3.04) |
| Delayed graft function, yes or no | 2.03 (1.38 to 3.01) |
| Any rejection | 0.67 (0.40 to 1.12) |
| Early indication biopsy | 2.12 (1.36 to 3.29) |
Multivariable model of effect of delayed graft function, histologic rejection in early indication biopsies, and baseline characteristics on death-censored graft failure as assessed by multivariable Cox proportional hazard analysis. Landmark analysis starting at 15 days post-transplantation. Six grafts were lost and two patients died within 14 days post-transplantation and were not included in analysis. 95% CI, 95% confidence interval; DSAs, donor-specific antibodies.