Table 3.

Univariate analysis for correlations between weight loss-induced changes in serum and urine mtND-1 and mtCOX-3 copy number and the changes in other variables in patients with obesity

Variables (Δ)	Δ serum mtND-1		Δ serum mtCOX-3		Δ urine mtND-1		Δ urine mtCOX-3
	r	P value	r	P value	r	P value	r	P value
Weight, kg	−0.046	0.769	0.024	0.877	−0.176	0.254	−0.109	0.480
BMI, kg/m2	0.119	0.446	0.070	0.655	0.210	0.172	0.150	0.332
Systolic BP, mm Hg	0.171	0.318	0.064	0.712	0.214	0.203	0.143	0.399
Diastolic BP, mm Hg	0.362*	0.030	0.272	0.108	0.109	0.522	0.108	0.524
eGFR CKD-EPI by cysC, mL/min/1.73 m2	−0.360*	0.047	−0.357*	0.049	0.225	0.216	0.234	0.198
AST	0.128	0.445	0.061	0.716	0.027	0.871	0.042	0.801
ALT	0.121	0.468	−0.032	0.848	0.023	0.889	0.073	0.659
Triglyceride, mg/dL	0.080	0.642	0.136	0.428	−0.270	0.106	−0.290	0.082
LDL cholesterol, mg/dL	−0.006	0.969	−0.080	0.628	−0.067	0.680	−0.071	0.661
HDL cholesterol, mg/dL	−0.016	0.927	−0.042	0.816	−0.004	0.983	−0.039	0.826
Glucose, mg/dL	0.091	0.582	0.067	0.686	0.052	0.750	−0.015	0.929
HbA1c	−0.003	0.985	−0.039	0.806	0.048	0.758	0.035	0.826
Urinary protein, mg/day	−0.250	0.175	−0.303	0.097	−0.040	0.829	−0.076	0.679
Urinary albumin, mg/day	−0.222	0.230	−0.233	0.208	−0.078	0.679	−0.114	0.540

Values are Pearson’s correlation coefficients and associated p values. Values in bold indicate statistically significant correlation at a value of p<0.05.

*P<0.05, **p<0.005.

ALT, alanine transaminase; AST, aspartate transaminase; BMI, body mass index; BP, blood pressure; CKD-EPI, CKD Epidemiology Collaboration; eGFR, estimated glomerular filtration rate; HbA1c, hemoglobin A1c; HDL, high-density lipoprotein; LDL, low-density lipoprotein; mtCOX-3, mitochondrial cytochrome-c oxidase 3; mtND-1, mitochondrial nicotinamide adenine dinucleotide dehydrogenase subunit-1.