Fig. 2. Views from crystal structures of cyclic boronate binding to KPC-2. Fo – Fc density calculated in the absence of ligand is shown as a green mesh, contoured to 3σ, for (A) vaborbactam (grey sticks) and (B) taniborbactam (yellow sticks). (C) Comparison of taniborbactam and vaborbactam in the KPC-2 active site. (D) An overlay of vaborbactam and taniborbactam KPC-2 structures (interactions shown as black and yellow dashes for vaborbactam and taniborbactam, respectively).
