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. 2020 Aug 12;216(2):359–379. doi: 10.1534/genetics.120.303292

Figure 6.

Figure 6

BRC-1-BRD-1 inhibits GFP::COSA-1 marked crossover (CO) precursors when a subset of chromosomes fails to form COs. (A) Number of COSA-1 foci in mid- to late-pachytene in indicated mutants; mean and 95% confidence intervals are shown. Letters/numbers above graph indicate which chromosomes are asynapsed in the different mutants. Statistical comparisons by Mann–Whitney *P < 0.05; **P < 0.001; ***P < 0.0001. Number of nuclei scored: gfp::cosa-1 = 97, gfp::cosa-1; brc-1(xoe4) = 194, gfp::cosa-1; brd-1(ok1623) = 103, gfp::cosa-1; him-8(me4) = 151, gfp::cosa-1; brc-1(xoe4); him-8(me4) = 183; gfp::cosa-1; brd-1(ok1623); him-8(me4) = 172, gfp::cosa-1; zim-2(tm547) = 125, gfp::cosa-1; brc-1(xoe4); zim-2(tm547) = 128; gfp::cosa-1; brd-1(ok1623); zim-2 = 84, gfp::cosa-1; zim-1(tm1813) = 120, gfp::cosa-1; brc-1(xoe4); zim-1(tm1813) = 100, gfp::cosa-1; brd-1(ok1623); zim-1(tm1813) = 97, gfp::cosa-1; zim-3(xoe15) = 308, gfp::cosa-1; brc-1(xoe4); zim-3(xoe15) = 133, gfp::cosa-1; brd-1(ok1623); zim-3(xoe15) = 145, gfp::cosa-1; syp-1(me17) = 271, gfp::cosa-1; brc-1(xoe4); syp-1(me17) = 281, gfp::cosa-1; brd-1(ok1623); syp-1(me17) = 344. (B) Half projections of late pachytene region showing GFP::COSA-1 (green) and DAPI (blue) in wild type, brc-1(xoe4), zim-1(tm1813) and brc-1(xoe4); zim-1(tm1813). Bar, 5 μm.