Table 1. Spearman’s correlation coefficients between various properties of the simulated region and the sum of the posterior probabilities for diploS/HIC’s hard and soft classes.
| Genome and demographic scenario | Strength of selection on CNEs | Number of selected sites in central window | Number of flanking selected sites | Total recombination rate |
|---|---|---|---|---|
| Human (equilibrium) | Same as exons | ρ = −0.038 (P = 0.90) | ρ = −0.048 (P = 0.13) | ρ = −0.21 (P = 2.3 × 10−11)a |
| Human (equilibrium) | 10-fold weaker | ρ = 0.044 (P = 0.16) | ρ = −0.027 (P = 0.38) | ρ = −0.18 (P = 7.8 × 10−9)a |
| Human (Tennessen) | Same as exons | ρ = 0.021 (P = 0.50) | ρ = −0.028 (P = 0.37) | ρ = −0.10 (P = 0.0011)a |
| Human (Tennessen) | 10-fold weaker | ρ = 0.020 (P = 0.53) | ρ = 0.028 (P = 0.37) | ρ = −0.11 (P = 2.7 × 10−4)a |
| Drosophila (Sheehan and Song) | Same as exons | ρ = 0.05 (P = 0.085) | ρ = −0.054 (P = 0.087) | ρ = − 0.15 (P = 3.9 × 10−6)a |
| Drosophila (Sheehan and Song) | 10-fold weaker | ρ = 0.13 (P = 2.7 < 10−15)a | ρ = −0.032 (P = 0.30) | ρ = −0.22 (P = 7.7 × 10−13)a |
All simulations were under either the real BGS model or the real BGS model with weaker selection on CNEs. BGS, background selection; CNE, conserved noncoding element; recomb, recombination.
a
Uncorrected P-values are shown marking correlations that are significant with α = 0.05 after Bonferroni correction.