Table 2.

Summary of phenotypes in Chd8 haploinsufficient mouse lines

	This study	Platt et al.	Katayama et al.	Gompers et al.	Suetterlin et al.	Jung et al.
Age range tested (weeks)	25–52	10–14	13–17	8–16	9–12	8–14
Body weight	Decrease (25 weeks)	Decrease (10 weeks)	No change (9 weeks)	No change	Decrease (5 weeks)	No change (3 weeks)
Brain weight or volume at birth	Increase	X	Increase	Increase	Increase	X
Pup survival, reared by Chd8 mutant dams	Reduced	X	X	X	X	X
Elevated plus maze
% open arm time	No change	X	Decrease	X	X	No change
Open field
Total distance	No change	Decrease	No change	No change	Decrease	Decrease
Rearing	Decrease	X	X	X	X	X
Center time	Decrease	Decrease	Decrease	X	No change	Decrease
Three chamber test
Sociability	No change	No change	No change	No change	Increase	No change
Novelty preference	Increase	Decrease	Decrease	X	X	No change
Entries	No change	No change	X	No change	X	X
Marble-bury assay	No change	No change	X	No change	Decrease	No change
Acoustic startle
Amplitude	No change	X	Decrease	X	X	X
Prepulse inhibition	No change	X	Increase	X	X	No change
Olfactory test	No change	X	X	X	X	No change

X indicates not conducted or not reported. Consult the indicated references for details as methodological differences may affect or limit comparisons between studies