FIGURE 3.

Mortality as a function of nadir native hemoglobin concentration in anemic patients for whom blood transfusion was not an option, comparing all hospitalized patients in the databases of Beliaev et al. ⁵¹ plus Guinn et al. ⁵⁵ (——) with patients treated with an HBOC, Hemopure, in an expanded access program (‐‐‐‐). ⁴⁴ Patients treated with the HBOC had improved survival (P = .0002, HR 0.56 [95% CI: 0.32‐0.71]) [Color figure can be viewed at wileyonlinelibrary.com]