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COXi use is associated with improved time-to-progression. Kaplan-Meier curves for time-to-progression in metastatic patients stratified by COXi use during first-course of ICI after diagnosis of metastatic disease for (A) melanoma cohort (n=90); (B) modified metastatic melanoma cohort (n=69) after Response Evaluation Criteria in Solid Tumors assessment; and (C) non-small cell lung cancer cohort (n=37). COXi, cyclo-oxygenase inhibitors; ICI, immune checkpoint inhibitor.
