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. 2020 Aug 17;152(10):e202012631. doi: 10.1085/jgp.202012631

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© 2020 Neginskaya et al.

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Figure 9. — The number of PTP channels and ionic conductance per single mitochondrion. (A and B) Each data point in A and B represents the ratio of the water flux through the whole mitoplast and water flux through the single pore with a diameter of 2 nm. This ratio reflects the estimation of the number of pores in the individual mitochondrion after PT activation with calcium. (A) Calculations based on the rate of mitochondrial swelling. Data points were collected from six individual experiments. (B) Calculations based on the rate of mitochondrial shrinkage. Data points were collected from two individual experiments. (C) Overall ionic conductance of the single mitochondrion during calcium-induced PT. Mean ± SEM. *, P < 0.05; n = 14 for swelling in 2 mM Ca²⁺; n = 15 for swelling in 200 µM Ca²⁺; n = 12 for shrinkage in 2 mM Ca²⁺/PEG 2000. V_max, maximum volume.