Table 1.
Patient demographics.
| Characteristic | US cohort |
Japan cohort |
||||
|---|---|---|---|---|---|---|
| |
Oophorectomy |
Ovarian conservation |
P-value | Oophorectomy |
Ovarian conservation |
P-value |
| Number | n = 1083 | n = 113 | n = 452 | n = 43 | ||
| Age (years) | 42.6 (±5.6) | 37.9 (±6.4) | <0.001 | 43.0 (±5.6) | 36.3 (±6.4) | <0.001 |
| <40 | 289 (26.7%) | 66 (58.4%) | 107 (23.7%) | 31 (72.1%) | ||
| ≥40 | 794 (73.3%) | 47 (41.6%) | 345 (76.3%) | 12 (27.9%) | ||
| Year | <0.001 | 0.602 | ||||
| 2000–2002 | 70 (6.5%) | 4 (3.5%) | 30 (6.6%) | 2 (4.7%) | ||
| 2003–2005 | 144 (13.3%) | 7 (6.2%) | 37 (8.2%) | 6 (14.0%) | ||
| 2006–2008 | 249 (23.0%) | 15 (13.3%) | 69 (15.3%) | 4 (9.3%) | ||
| 2009–2011 | 329 (30.4%) | 30 (26.5%) | 138 (30.5%) | 14 (32.6%) | ||
| 2012–2014 | 291 (26.9%) | 57 (50.4%) | 178 (39.4%) | 17 (39.5%) | ||
| Race/ethnicity | <0.001 | n/a | ||||
| White | 645 (59.6%) | 49 (43.4%) | ||||
| Black | 70 (6.5%) | 5 (4.4%) | ||||
| Hispanic | 202 (18.7%) | 41 (36.3%) | ||||
| Asian | 46 (4.2%) | 12 (10.6%) | 452 (100%) | 43 (100%) | ||
| Others | 20 (1.8%) | 3 (2.7%) | ||||
| Unknown | 100 (9.2%) | 3 (2.7%) | ||||
| Obesity | 38.4 (±11.6) | 37.9 (±10.9) | 0.927 | 25.9 (±7.1) | 24.1 (±7.0) | 0.378 |
| Normal/under weight | 130 (12.0%) | 13 (11.5%) | 247 (54.6%) | 28 (65.1%) | ||
| Overweight | 142 (13.1%) | 15 (13.3%) | 83 (18.4%) | 6 (14.0%) | ||
| Class I | 168 (15.5%) | 17 (15.0%) | 47 (10.4%) | 4 (9.3%) | ||
| Class II | 158 (14.6%) | 18 (15.9%) | 34 (7.5%) | 0 | ||
| Class III | 444 (41.0%) | 48 (42.5%) | 23 (5.1%) | 2 (4.7%) | ||
| Unknown | 41 (3.8%) | 2 (1.8%) | 18 (4.0%) | 3 (7.0%) | ||
| Parity | 0.004 | 0.005 | ||||
| 0 | 519 (47.9%) | 71 (62.8%) | 205 (45.4%) | 26 (60.5%) | ||
| 1 | 170 (15.7%) | 19 (16.8%) | 58 (12.8%) | 4 (9.3%) | ||
| ≥2 | 344 (31.8%) | 18 (15.9%) | 121 (26.8%) | 2 (4.7%) | ||
| Unknown | 50 (4.6%) | 5 (4.4%) | 68 (15.0%) | 11 (25.6%) | ||
| Diabetes mellitus | 0.068 | 0.999 | ||||
| No | 849 (78.4%) | 98 (86.7%) | 411 (90.9%) | 40 (93.0%) | ||
| Yes | 187 (17.3%) | 14 (12.4%) | 41 (9.1%) | 3 (7.0%) | ||
| Unknown | 47 (4.3%) | 1 (0.9%) | 0 | 0 | ||
| Hypertension | 0.001 | 0.207 | ||||
| No | 730 (67.4%) | 95 (84.1%) | 398 (88.1%) | 41 (95.3%) | ||
| Yes | 306 (28.3%) | 17 (15.0%) | 54 (11.9%) | 2 (4.7%) | ||
| Unknown | 47 (4.3%) | 1 (0.9%) | 0 | 0 | ||
| Hypercholesterolemia | 0.027 | 0.501 | ||||
| No | 893 (82.5%) | 104 (92.0%) | 423 (93.6%) | 42 (97.7%) | ||
| Yes | 143 (13.2%) | 8 (7.1%) | 29 (6.4%) | 1 (2.3%) | ||
| Unknown | 47 (4.3%) | 1 (0.9%) | 0 | 0 | ||
| Cigarette use | 0.647 | 0.272 | ||||
| No | 843 (77.8%) | 90 (79.6%) | 267 (59.1%) | 24 (55.8%) | ||
| Yes | 204 (18.8%) | 18 (15.9%) | 82 (18.1%) | 5 (11.6%) | ||
| Unknown | 36 (3.3%) | 5 (4.4%) | 103 (22.8%) | 14 (32.6%) | ||
| Metformin | 0.947 | 0.686 | ||||
| No | 917 (84.7%) | 97 (85.8%) | 441 (97.6%) | 42 (97.7%) | ||
| Yes | 145 (13.4%) | 14 (12.4%) | 6 (1.3%) | 1 (2.3%) | ||
| Unknown | 21 (1.9%) | 2 (1.8%) | 5 (1.1%) | 0 | ||
| Statin | 0.385 | 0.317 | ||||
| No | 963 (88.9%) | 105 (92.9%) | 429 (94.9%) | 43 (100%) | ||
| Yes | 99 (9.1%) | 6 (5.3%) | 16 (3.5%) | 0 | ||
| Unknown | 21 (1.9%) | 2 (1.8%) | 7 (1.5%) | 0 | ||
| Aspirin | 0.224 | 0.557 | ||||
| No | 1002 (92.5%) | 109 (96.5%) | 440 (97.3%) | 43 (8.8%) | ||
| Yes | 60 (5.5%) | 2 (1.8%) | 7 (1.5%) | 0 | ||
| Unknown | 21 (1.9%) | 2 (1.8%) | 5 (1.1%) | 0 | ||
| Beta-blocker | 0.805 | 0.615 | ||||
| No | 966 (89.2%) | 103 (91.2%) | 442 (97.8%) | 43 (100%) | ||
| Yes | 96 (8.9%) | 8 (7.1%) | 2 (0.4%) | 0 | ||
| Unknown | 21 (1.9%) | 2 (1.8%) | 8 (1.8%) | 0 | ||
| Prior malignancy | 0.455 | 0.682 | ||||
| None | 1025 (94.6%) | 111 (98.2%) | 429 (94.9%) | 43 (100%) | ||
| Breast | 18 (1.7%) | 0 | 12 (2.7%) | 0 | ||
| Ovarian | 5 (0.5%) | 0 | 1 (0.2%) | 0 | ||
| Colorectal | 9 (0.8%) | 0 | 3 (0.7%) | 0 | ||
| Others/unknown | 26 (2.4%) | 2 (1.8%) | 7 (1.5%) | 0 | ||
| CA-125 (IU/L) | 0.363 | 0.215 | ||||
| <35 | 258 (23.8%) | 33 (29.2%) | 340 (75.2%) | 36 (83.7%) | ||
| ≥35 | 33 (3.0%) | 2 (1.8%) | 64 (14.2%) | 2 (4.7%) | ||
| Unknown | 792 (73.1%) | 78 (69.0%) | 48 (10.6%) | 5 (11.6%) | ||
| Prior hormone therapy | <0.001 | <0.001 | ||||
| No | 887 (81.9%) | 80 (70.8%) | 423 (93.6%) | 31 (72.1%) | ||
| Yes | 133 (12.3%) | 31 (27.4%) | 16 (3.5%) | 11 (25.6%) | ||
| Unknown | 63 (5.8%) | 2 (1.8%) | 13 (2.9%) | 1 (2.3%) | ||
Mean (±standard deviation) or number (percent per column) is shown. P-values for univariable analysis. Significant P-values are emboldened.