Table 2. Mapped HPV-16 CD4+ T cell epitopes.
| Antigen | Epitope | HLA restriction | Number of patients |
|---|---|---|---|
| HPV-16-E1 | VSFSELVRPFKSNKSTCCD | DRB1*15:01 | 1 |
| FLRYQGVEFMSFLTALKRF | Not defined | 1 | |
| AAMLAKFKELYGVSFSELV | Not defined | 1 | |
| PSIADSIKTLLQQYC | Not defined | 1 | |
| GWFYVEAVVEKKTGD | Not defined | 1 | |
| CTFELSQMVQWAYDN | Not defined | 1 | |
| AKFKELYGVSFSELVRPFK | DRB1*07:01 | 1 | |
| YDNDIVDDSEIAYKYAQLA | Not defined | 1 | |
| QGIPKKNCILLYGAANTGK | Not defined | 1 | |
| LFGMSLMKFLQGSVICFVN | Not defined | 1 | |
| QGVEFMSFLTALKKRF | DRB1*09:01 | 1 | |
| LFGMSLMKFLQGSVICFVN | Not defined | 1 | |
| WKSFFSRTWSRLSLH | DRB1*04:01 | 3 | |
| FMSFLTALKRFLQGIPKKN | DRB1*11:04, DRB*04:01 | 2 | |
| VEAVVEKKTGDAISDDENE | ND | 1 | |
| HPV-16-E2 | SVDSAPILTAFNSSHa | DQA1*05:01–DQB1*03:01 | 1 |
| LRYRFKKHCTLYYTAVa | DRB1*15:01 | 2 | |
| HIDYWKHMRLECALYa | DRB1*13:02 | 2 | |
| NVCQDKILTHYENDSTDLRa | Not defined | 1 | |
| QVVPTLAVSKNKALQAIELa | Not defined | 1 | |
| VSLEVYLTAPTGCIKKHGYa | Not defined | 1 | |
| HPV-16-E6 | KQRFHNIRGRWTGRCMSCCa | DRB1*15:01/DQB1*03:01 | 3 |
| EKQRHLDKKQRFHNIRGRWa | DRB1*13:02/DQR1*13:03 | 2 | |
| VYDFAFRDLCIVYRDa | Not defined | 1 | |
| AFRDLCIVYRDGNPYAVCDa | Not defined | 2 | |
| VCDKCLKFYSKISEYRHYCa | Not defined | 1 | |
| HPV-16-E7 | VQSTHVDIRTLEDLLMGTLa | DQA1*05:01–DQB1*03:01 | 2 |
| YEQLNDSSEEEDEIDa | DQB1*06:09 | 1 | |
| TPTLHEYMLDLQPETTDLYa | Not defined | 2 |
a
Previously published epitope sequences.