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. 2020 Jul 29;217(10):e20191871. doi: 10.1084/jem.20191871

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© 2020 Tao et al.

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Figure 1. — Immunohistochemical evaluation of AKT and its downstream target proteins phosphorylation in human primary ganglioneuroma and poorly differentiated neuroblastoma samples. (A) H&E staining and IHC with phosphorylated AKT (p-AKT; Ser473) and pan-AKT for a representative human primary ganglioneuroma (GN) and poorly differentiated neuroblastoma (NB). Scale bar, 20 µm. Protein expression is indicated by brown staining. (B) The percentage of p-AKT (Ser473), pan-AKT, phosphorylated mTOR (p-mTOR; Ser2448), mTOR, phosphorylated S6 ribosomal protein (p-S6; Ser235/236), and S6-positive cases in GN and NB. The number of positive and total cases is indicated on top of each column. The significance of the ratios of positive to negative tumors by IHC for these target proteins between GN and NB were determined by two-sided Fisher's exact test. ns, not significant; *, P < 0.05; ****, P < 0.0001.