Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Jul 22;217(10):e20191761. doi: 10.1084/jem.20191761

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2020 Poholek et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).

PMC Copyright notice

Figure 4. — STAT3 deletion in effector Th17 cells does not phenocopy IL-23R blockade. (A) Relative gene expression for select IL-23 targets, generated by RNA sequencing from indicated YFP⁺ cells sorted from dLNs on day 10 after immunization. (B) Integrin β3 expression analyzed by flow cytometry in YFP⁺ and YFP⁻ CD4⁺ dLN cells from Th17^ΔSTAT3 and Th17^ctrl mice 10 d after immunization with MOG(35–55) in CFA. Plots are representative of three or four mice per group in three experiments. (C) Foxp3 expression in YFP⁺ cells analyzed by flow cytometry on day 10 after immunization. FMO, fluorescence minus one. Data points show values for individual mice with mean ± SD, pooled from two experiments. Differences between groups were not significant by one-way ANOVA (A) and Student’s t test (C).