Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Jul 22;217(10):e20191761. doi: 10.1084/jem.20191761

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2020 Poholek et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).

PMC Copyright notice

Figure 5. — STAT3 counterregulates STAT1 activation by IL-6 in effector Th17 cells. (A) Heatmap of relative gene expression for known STAT1 targets generated by RNA sequencing from indicated YFP⁺ cells sorted from dLN on day 10 after immunization. (B–E) dLN cells were isolated from indicated mice on day 10 after immunization with MOG(35–55) in CFA and stimulated with IL-6 (B and C) or IL-23 (D and E) for indicated times. (B and D) Percentage of YFP⁺ cells expressing pSTAT1. (C and E) Geometric mean fluorescence intensity (GMFI) of pSTAT1-expressing YFP⁺ cells. Data points show values for individual mice with mean ± SD, pooled from two experiments. *, P < 0.05; **, P < 0.01; ***, P < 0.001; ****, P < 0.0001, one-way ANOVA.