Table 6.
Antiviral activity of compounds 1 (a -b) - 4(a - b) evaluated in Vero cell culture.
| Compound | Concentration unit | Minimum cytotoxic concentrationa (MCC) | EC50b |
SIc (Yellow Fever Virus) | |||||
|---|---|---|---|---|---|---|---|---|---|
| Para-influenza-3 virus | Reovirus-1 | Sindbis virus | Coxsackie virus B4 | Punta Toro virus | Yellow Fever virus | ||||
| 1a | μg/mL | >100 | >100 | >100 | >100 | >100 | >100 | >100 | 1 |
| 1b | μg/mL | >100 | >100 | >100 | >100 | >100 | >100 | >100 | 1 |
| 2a | μg/mL | ≥100 | >100 | >100 | >100 | >100 | >100 | >100 | 1 |
| 2b | μg/mL | >100 (> 0.391μM) | >100 | >100 | >100 | >100 | >100 | 6.0 (0.0234μM) | > 16.64 |
| μg/mL | ≥100 (≥ 0.391μM) | >100 | >100 | >100 | >100 | >100 | 2.0 (0.7824 × 10−2μM) | ≥ 50 | |
| 3a | μg/mL | 100 | >100 | >100 | >100 | >100 | >100 | >100 | 1 |
| 3b | μg/mL | >100 | >100 | >100 | >100 | >100 | >100 | >100 | 1 |
| 4a | μg/mL | >100 | >100 | >100 | >100 | >100 | >100 | >100 | 1 |
| 4b | μg/mL | ≥100 | >100 | >100 | >100 | >100 | >100 | >100 | 1 |
| DS - 10.000 | μg/mL | >100 (0.01μM) | >100 | >100 | 20 | 1.8 | 72 | 0.8 (8 × 10−5 μM) | 125 |
| Ribavirin | μM | >250 | 250 | >250 | >250 | >250 | >250 | >250 | 1 |
| Mycophenolic acid | μM | >100 | 0.6 | 6.0 | 8.9 | >100 | 14 | 0.8 | 125 |
a
Required to cause a microscopically detectable alteration of normal cell morphology.
b
Required to reduce virus-induced cytopathogenicity by 50 %.
c
Selectivity Index (ratio of MCC to EC50).