Table 5.

Effect of trazodone (T), CBD (C), CBD by trazodone interaction (C*T), time (Pre-Noise and Noise), CBD by trazodone by time interaction (C*T*Time), and period on the duration of behavioral parameters (s) for 1-min immediately prior to (Pre-Noise) and the first minute (Noise) of the noise-induced fear response tests administered after each 7-d treatment period.

Parameter, s	Treatment				SE1	P-value
	Control	Trazodone (T)	CBD (C)	T+C		Trazodone	CBD	C*T	Time	C*T*Time	Period
Inactive	55.35	56.33	55.21	56.26	1.214	0.329	0.918	0.971	0.011	0.092	0.993
Facing door	37.45	33.90	34.96	37.70	4.198	0.872	0.796	0.217	0.561	0.556	0.786
Glancing around	16.90	15.65	17.93	15.91	3.460	0.396	0.736	0.841	<.001	0.142	0.819
Other eyes	5.10	13.33	4.10	5.48	1.885	0.044	0.072	0.182	<.001	0.469	0.792
Ears relaxed	11.37	7.76	12.35	11.43	4.913	0.179	0.168	0.422	<.001	0.868	0.567
Ears erect	29.33	34.29	29.93	29.80	5.614	0.304	0.408	0.279	<.001	0.747	0.982
Ears moving	19.25	17.79	17.20	18.78	2.076	0.970	0.742	0.351	<.001	0.457	0.493
Tail relaxed	37.90	49.86	38.93	50.96	4.857	0.001	0.753	0.992	0.611	0.898	0.990
Tail stiff	18.45	5.55	16.39	6.65	4.582	0.002	0.887	0.644	0.010	0.757	0.896

Treatment T+C indicates the combination treatment of CBD and trazodone.

¹The standard error (SE) of the back transformed data was calculated from the confidence limits of the transformed data as follows: SE = (back-transformed upper limit—back-transformed lower limit)/3.92.

Parameters were not normally distributed and were analyzed using the natural logarithm. Data were back transformed for reporting purposes.