Table 2.
Univariate and multivariate analysis of tumor-free survival in HCC patients.
| Clinicopathologic parameters | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
| HR (95% CI) | P | HR (95% CI) | P | |
| Age (<60 vs. ≥60) | 0.734 (0.432-1.246) | 0.252 | ||
| Gender (female vs. male) | 1.397 (0.559-3.490) | 0.474 | ||
| Hepatitis B (negative vs. positive) | 1.608 (0.763-3.386) | 0.212 | ||
| AFP (<400 vs. ≥400) | 1.033 (0.618-1.725) | 0.901 | ||
| Cirrhosis (present vs. absent) | 1.172 (0.698-1.968) | 0.549 | ||
| Microvascular invasion (present vs. absent) | 1.272 (0.460-3.520) | 0.643 | ||
| Tumor differentiation (low vs. high/moderate) | 0.760 (0.457-1.262) | 0.289 | ||
| Capsular invasion (present vs. absent) | 1.521 (0.904-2.560) | 0.114 | ||
| Multiple lesions (present vs. absent) | 1.783 (0.980-3.242) | 0.058 | 1.189 (0.546-2.593) | 0.663 |
| Vessel carcinoma embolus (present vs. absent) | 1.699 (0.957-3.016) | 0.071 | 1.384 (0.771-2.485) | 0.276 |
| TNM stage (I~II vs. III~IV) | 2.006 (1.195-3.369) | 0.008 | 1.577 (0.922-2.699) | 0.097 |
| Tumor diameter (<5 cm vs. ≥5 cm) | 2.604 (1.402-4.839) | 0.002 | 2.154 (1.140-4.070) | 0.018∗ |
| SNORA71A expression (low vs. high) | 0.385 (0.228-0.650) | <0.001 | 0.450 (0.263-0.770) | 0.004∗ |
AFP = alpha fetal protein; TNM = tumor-node-metastasis; HR = hazard ratio; ∗P < 0.05 was considered statistically significant.