Table 3.
Univariate and multivariate analysis of overall survival in HCC patients.
| Clinicopathologic parameters | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
| HR (95% CI) | P | HR (95% CI) | P | |
| Age (<60 vs. ≥60) | 1.067 (0.514-2.216) | 0.861 | ||
| Gender (female vs. male) | 0.541 (0.231-1.266) | 0.157 | ||
| Hepatitis B (negative vs. positive) | 0.895 (0.365-2.191) | 0.808 | ||
| AFP (<400 vs. ≥400) | 1.398 (0.682-2.866) | 0.360 | ||
| Cirrhosis (present vs. absent) | 1.208 (0.575-2.540) | 0.618 | ||
| Microvascular invasion (present vs. absent) | 1.791 (0.540-5.938) | 0.341 | ||
| Tumor differentiation (low vs. high/moderate) | 0.876 (0.424-1.809) | 0.720 | ||
| Capsular invasion (present vs. absent) | 2.175 (1.063-4.452) | 0.033 | 1.436 (0.662-3.116) | 0.360 |
| Tumor diameter (<5 cm vs. ≥5 cm) | 3.480 (1.210-10.005) | 0.021 | 1.952 (0.620-6.143) | 0.253 |
| Multiple lesions (present vs. absent) | 2.410 (1.140-5.095) | 0.021 | 1.125 (0.429-2.952) | 0.810 |
| Vessel carcinoma embolus (present vs. absent) | 2.075 (0.949-4.538) | 0.068 | 2.047 (0.898-4.665) | 0.088 |
| TNM stage (I~II vs. III~IV) | 3.061 (1.480-6.331) | 0.003 | 2.637 (1.263-5.507) | 0.010∗ |
| SNORA71A expression (low vs. high) | 0.257 (0.114-0.580) | 0.001 | 0.289 (0.127-0.657) | 0.003∗ |
AFP = alpha fetal protein; TNM = tumor-node-metastasis; HR = hazard ratio; ∗P < 0.05 was considered statistically significant.