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The factors that cause cardiovascular disease are complex, including NADPH, NOX, eNOS, NO, and ROS. ROS is the most obviously biological markers of oxidative stress. The increase in oxidative stress directly causes lipid peroxidation, protein and enzyme denaturation, nucleic acid DNA damage, and other mechanisms of the myocardial cell membrane or cardiovascular epithelial cells. These are also important pathways for the action of antioxidant drugs.
