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. Author manuscript; available in PMC: 2020 Oct 6.
Published in final edited form as: J Am Chem Soc. 2020 Aug 24;142(35):14831–14837. doi: 10.1021/jacs.0c07043

Figure 1.

Figure 1.

A) Examples of difluroromethylene-containing medicinal compounds and properties of difluoromethylenes as bioisosteres. B) Catalytic cycle for oxidative bromonium formation leading to enantioenriched alkyl bromides.