TABLE 2.

miRs that regulate embryo implantation.

miR	Phenotype	Target (s)	Affect implantation in animal model	References
Hsa-miR-200c	Overexpression of miR-200c in RL95-2 and Ishikawa cells impair receptive ability in vitro	FUT4↓	Yes (mouse)	Zheng et al., 2017
Hsa-miR-661	Secreted by non-implanted embryo and transferred to HEECs to affect their adhesive capacity in vitro	PVRL1↓	Not available	Cuman et al., 2015
	Overexpression of miR-661 in HEECs in vitro impairs adhesion	MDM2↓	Not available	Winship et al., 2018
Hsa-miR-181a	Inhibition of miR-181a compromises human endometrial stromal cell decidualization in vitro	KLF12↓	Yes (mouse)	Chu et al., 2015; Zhang et al., 2015
Hsa-miR-212	hCG stimulates miR-212 expression in Ishikawa cells to favor spheroid adhesion in vitro	OLFM1↓, CTBP1↓	Not available	Kottawatta et al., 2015
Hsa-miR-145	Overexpression of miR-145 in Ishikawa cells affects mouse embryo attachment in vitro	IGF1R↓	Not available	Kang et al., 2015
Hsa-miR-30d	Human endometrial secreted miR-30d is taken up by mouse pre-implantation embryo and increases embryo adhesion in vitro	Itgb3↑, Itga7↑, Cdh5↑	Yes (Mouse)	Vilella et al., 2015; Balaguer et al., 2019
	Overexpression of miR-30d in Ishikawa cells facilitates adhesion in vitro	SNAI1↓	Yes (Mouse)	Cai et al., 2016; Balaguer et al., 2019
Hsa-miR-125b	Overexpression of miR-125b in HEECs inhibits cell migration and invasion in vitro	MMP26↓	Yes (Mouse)	Chen et al., 2016
Hsa-miR-29c	Overexpression of miR-29c in HEECs impairs adhesion in vitro	COL4A1↓	Not available	Griffiths et al., 2019
Hsa-miR-590-3p	Overexpression of miR-590-3p in HEECs in vitro impairs adhesion	N/A	Not available	Takamura et al., 2019
Hsa-miR-140	Overexpression of miR-140 in RL95-2 endometrial epithelial cells impairs adhesion and spheroid outgrowth in vitro	N/A	Yes (Rat)	Sirohi et al., 2018