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. 2020 Sep 22;10:1775. doi: 10.3389/fonc.2020.01775

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Copyright © 2020 Esser, Branchi, Leonardelli, Pelusi, Simon, Klümper, Ellinger, Hauser, Gonzalez-Carmona, Ritter, Kristiansen, Schorle, Hölzel and Toma.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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RNA sequencing shows close molecular relationship. The close molecular relationship of the samples’ gene expression profiles was projected onto the first two principal components in a PCA plot (A). Volcano plot displaying the differentially expressed genes. Genes of interest, which are associated with inflammatory response and IL-2 STAT 5 signaling, are indicated in the up-regulated genes, genes expressed in blood are indicated in down regulated genes (B). Genes correlated with inflammatory response were up-regulated. NES = normalized enrichment score (C). Genes correlated with IL-2 STAT5 signaling were up-regulated. NES = normalized enrichment score (D).