Fig. 5.

Inhibition of fatty acid metabolism is detrimental to cellular and organismal survival in AD models. a representative images of active caspase-3 immunofluorescence following 8 h of exposure to vehicle (DMSO control) or CPT-1 inhibitor etomoxir (40 μM) with quantified fluorescent intensity of active caspase-3 (b). Quantification of percent C. elegans survival following etomoxir treatment from L4 stage to day 6 in wild-type (N2) (c), neuronal expressing amyloid β strain (CL2355) (d), neuronal expressing non-aggregating tau (BR5271) (e), or aggregating neuronal tau (BR5270) (f), p-values from 2-tailed unpaired student’s t-tests are shown on corresponding graphs