Skip to main content
. Author manuscript; available in PMC: 2021 Jan 1.
Published in final edited form as: Acta Neuropathol. 2020 Apr 24;140(1):25–47. doi: 10.1007/s00401-020-02152-8

Fig. 6.

Fig. 6

Sex-dependent serum metabolic alterations in early onset AD patients. a Male (blue) non-converters/ cognitively normal controls (CON, n = 64) and converters/ Alzheimer’s (AD, n = 48) subject’s plasma levels of arachidonic acid, oleic acid, threonine and palmitoleic acid. b Female (red) cognitively normal controls (CON, n = 55) and Alzheimer’s (AD, n = 59) subject’s relative plasma levels of arachidonic acid, oleic acid, linolenic acid, and hypoxanthine. c Sex combined analysis of CON (n = 119) and AD (n = 107) samples arachidonic acid, oleic acid, methionine, and d Partial lease squares discriminant analysis (PLS-DA) important metabolites for discrimination between CON and AD groups. e Metabolite set enrichment (MSE) pathway analysis. f Follow-up plasma levels of male (blue) and g) female (red) metabolites. h Sex combined analysis of plasma metabolite changes at follow-up. i Partial lease squares discriminant analysis (PLS-DA) important metabolites for discrimination between CN and AD groups at follow-up. j Metabolite set enrichment (MSE) pathway analysis. Statistical analysis was performed with Stata 13.0. PLS-DA and MSE analysis were performed with MetaboAnalyst V4.0