Figure 1.

Hippocampal neurogenesis, stress, and antidepressant treatment: schematic representation of a coronal section through a mouse brain. The expanded views in the panels illustrate the dentate gyrus of the hippocampus with the cell bodies of young neurons (red) in the subgranular layer and dendritic projections traversing the granule cell layer. Baseline neurogenesis is enhanced by antidepressants, reduced by stress and the stress-induced reduction is reversed with antidepressant treatment. The expanded views in the bottom panels show a pyramidal neuron in CA3 with basal and apical (red) dendrites extending outside the pyramidal cell layer (gray). Stress reduces the baseline arborization of apical dendrites. Tianeptine, but not serotonin reuptake inhibitors, reverses the effect of stress on dendritic arborization.