Table 1. Predictive variables to consider in the model.

Variable	Nature	Variable type	Instrument/stand
Age	Continuous (years)	Predictive	Identification
Sex	Dichotomous (Yes/No)	Predictive	Identification
Urticaria time	Continuous (Months)	Predictive	Self-report
Angioedema	Dichotomous (Yes/No)	Predictive	Self-report/Photo
Inducible urticaria	Dichotomous (Yes/No)	Predictive	Self-report/Challenge test
UAS7 baseline	Continuous	Predictive	UAS7 scale baseline
Autoimmunity	Dichotomous (Yes/No)	Predictive	Dx autoimmune diseases and paraclinical test
Anxiety and/or depression	Dichotomous (Yes/No)	Predictive	Goldberg scale
Atopy	Dichotomous (Yes/No)	Predictive	SPT and/or sIgE
IgE TPO	Continuous (Unit/ml)	Predictive	Paraclinical test
IgG TPO	Continuous (Unit/ml)	Predictive	Paraclinical test
Eosinophils	Continuous (count/ml)	Predictive	Paraclinical test
C reactive protein	Continuous (count/ml)	Predictive	Paraclinical test
AINEs hypersensitivity	Dichotomous (Yes/No)	Predictive	Self-report/Challenge test
Body mass index	Continuous	Predictive	Height and weight
UAS7 final	Continuous	Outcome	UAS7 scale final*

As the main outcome, clinical control (UAS7 control <6 points or no UAS7 control >7) will be determined after at least four weeks with the conventional dose and increased dose of an antihistamine.