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Inhibition of HIV-1 capture and transmission by DC-SIGN+ cells to human CD4+ T lymphocytes
| CBA | EC50a (μM) |
|
|---|---|---|
| capture | transmissionb | |
| NICTABA | >1.3 | 0.14 |
| UDA | 0.44 | 0.61 |
| HHA | 0.01 | 0.06 |
aEC50, the effective concentration of CBA necessary to inhibit HIV-1 capture by Raji DC-SIGN and the transmission of DC-SIGN-captured virus to uninfected CD4+ C8166 T cells by 50%.
bIn co-cultivation cultures with CD4+ C8166 T cells, samples were taken 44 h post-co-cultivation.
