Table 1.
Clinical characteristics of the subjects
| Characteristics | Pregnant women cohort (n = 163) | Metabolomics detection samples | ||||
|---|---|---|---|---|---|---|
| PROM cases (n = 36) | Controls (n = 87) | Lost to follow-up (n = 40) | PROM cases (n = 10) | Controls (n = 10) | P value | |
| Maternal agea | 29.1 (22–39) | 29.5 (19–40) | 29.3 (21–41) | 27.4 (22–32) | 29.5 (22–36) | 0.23† |
| Nulliparity | 32 | 78 | 34 | 7 | 6 | 0.64‡ |
| White blood cell at admission (× 109/L) | 8.6 (6.1–13.1) | 8.1 (5.1–10.2) | – | 9.0 (6.2–12.7) | 8.0 (5.2–9.6) | 0.08† |
| Positive genital cultures at admission | 1 | 4 | 0 | 0 | 0 | – |
| Gestational age at sampling (weeks) a | 33.3 (31.0–36.6) | 33.5 (31.5–36.5) | 33.3 (31.4–36.0) | 33.9 (32.0–35.1) | 34.2 (32.8–36.0) | 0.73† |
| Steroid administration | 0 | 0 | 0 | 0 | 0 | – |
| Tocolysis treatment | 1 | 1 | – | 1 | 0 | 0.30‡ |
| Gestational age at delivery (weeks)a | 38.4 (34.7–40.1) | 39.4 (34.8–40.8) | – | 38.9 (37.9–39.4) | 38.7 (37.4–39.9) | 0.33† |
| Latency from sampling to delivery (weeks)a | 5.3 (0.5–7.8) | 5.8 (2.3–8.3) | – | 5.3 (3.2–7.1) | 4.5 (3.1–7.6) | 0.17† |
| Baby weight at birth (g)a | 3375 (2640–4200) | 3369 (2500–4500) | – | 3210 (2960–3700) | 3180 (2760–3780) | 0.83† |
| Baby gender (male/female) | 16/20 | 35/52 | – | 4/6 | 5/5 | 0.65‡ |
PROM, premature rupture of membranes
aValues are presented as median (mix-max)
†Independent-sample T test
‡Chi-square test