Table 2. Scope of Deuteration in Tandem Cyclizationa.
Reaction conditions: N-heterocycle 1 (0.5 mmol), haloarylalkyne 2 (0.5 mmol), CuI (5 mol %), BtCH2OH (10 mol %), and KOtBu (1.4 equiv) in 2.0 mL of DMSO-d6 at 120 °C for 18 h.
Isolated yields.
Reaction conditions: N-heterocycle 1 (0.5 mmol), haloarylalkyne 2 (0.5 mmol), CuI (5 mol %), BtCH2OH (10 mol %), and KOtBu (1.4 equiv) in 2.0 mL of DMSO-d6 at 120 °C for 18 h.
Isolated yields.