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. 2018 Sep 5;3(9):10612–10623. doi: 10.1021/acsomega.8b01329

Table 2. Scope of Deuteration in Tandem Cyclizationa.

graphic file with name ao-2018-013297_0012.jpg

graphic file with name ao-2018-013297_0013.jpg

a

Reaction conditions: N-heterocycle 1 (0.5 mmol), haloarylalkyne 2 (0.5 mmol), CuI (5 mol %), BtCH2OH (10 mol %), and KOtBu (1.4 equiv) in 2.0 mL of DMSO-d6 at 120 °C for 18 h.

b

Isolated yields.