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. 2020 Oct 2;12:9563–9575. doi: 10.2147/CMAR.S262007

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© 2020 Huang et al.

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MiR-455-3p restoration blocked CRC development in vitro by targeting MYO6. HCT116 and SW620 cells were introduced with miR-455-3p, miR-NC, miR-455-3p+MYO6 or miR-455-3p+vector. (A) The expression of MYO6 in these transfected cells was quantified by Western blot. (B–D) Cell proliferation was evaluated by MTT assay and colony formation assay in indicated cells. (E) Cell apoptosis was investigated by flow cytometry assay in indicated cells. (F and G) The expression of Bax, Bcl-2 and c-caspase-3 in indicated cells was quantified by Western blot. (H and I) Cell cycle distribution in indicated cells was monitored using flow cytometry assay. (J and K) Cell migration and invasion in indicated cells were determined using transwell assay. *P<0.05.