Table 12.
Summary table of findings classified by rs number from sensitivity analysisa
| Rs No. and gene name | No. of studies that reported statistically significant associations | First author, reference No. | No. of studies that reported absence of statistically significant associations | First author, reference No. |
|---|---|---|---|---|
| Aryl hydrocarbon receptor (AHR) | 1 | rs2066853 Ziv-Gal 2012 (14) | - | - |
| Aryl-hydrocarbon receptor repressor (AHRR) | – | – | 1 | rs2292596 Ziv-Gal 2012 (14) |
| Aryl hydrocarbon receptor nuclear translocator (ARNT) | – | – | 1 | rs2228099 Ziv-Gal 2012 (14) |
| Catechol-O-methyltransferase (COMT) | 1 | rs4680 Butts 2012 (20)b | 1 | rs4680 Rebbeck 2010 (3) |
| Cytochrome P450 family 1 subfamily A member 1 (CYP1A1) | 1 | rs2606345 Crandall 2006 (23) | 1 | rs1048943 c (CYP1A1m2, missense variant) Woods 2006 (15) |
| Cytochrome P450 family 1 subfamily A member 2 (CYP1A2) | 1 | rs762551 Butts 2012 (20)d | 1 | rs762551 Rebbeck 2010 (3) |
| Cytochrome P450 family 1 subfamily B member 1 (CYP1B1) | 4 | rs1056836, rs1800440, Butts 2012 (20)e; rs10012 Candrakova 2018 (21); rs1056836 Rebbeck 2010 (3) rs1800440 Ziv-Gal 2012 (14); rs1056836f (Leu->Val at codon 432) Visvanathan 2005 (17) | 4 | rs1056827; rs1056836; rs1800440 Candrakova 2018 (21); rs1056836 Crandall 2006 (23); rs1800440 Rebbeck 2010 (3), rs1056827g (CYP1B1*2, missense variant); rs1056836h (CYP1B1*3, missense variant) Woods 2006 (15); rs1056836i (Leu432Val) Luptakova 2012 (29) |
| Cytochrome P450 family 3 subfamily A member 4 (CYP3A4) | – | – | 2 | rs2740574 Butts 2012 (185)j; rs2740574 Rebbeck 2010 (3) |
| Cytochrome P450 family 17 subfamily A member 1 (CYP17A1) | 2 | rs743572 k (MspA1 5’ untranslated region variant) Massad-Costa 2008 (26); rs743572l (MspA1 5’ untranslated region variant) Visvanathan 2005 (17) | ||
| Cytochrome P450 family 19 subfamily A member 1 (CYP19A1) | – | - | 2 | rs700519 Rebbeck 2010 (3); rs2389 Woods 2018 (16) |
| Estrogen receptor 1 (ESR1) | 1 | rs2234693 Malacara 2004 (25) | 2 | rs9340799 Malacara 2004 (25), rs 9340799m (ESRXbaI, intron variant); rs2234693n (ESR1PvuII, intron variant) Woods 2006 (15), rs9340799 (ESRXbaI) Aguilar Zavala 2012 (30), rs2234693p (ESR1PvuII, intron variant) Aguilar-Zavala 2012 (30) |
| Estrogen receptor 2 (ESR2) | 1 | Cytosine-adenine dinucleotide repeat length in intron 5 Takeo 2005 (18) | ||
| Hydroxysteroid 17-β dehydrogenase 1 (HSD17B1) | 2 | rs2830; rs592389; rs615942 Crandall 2006; rs615942; rs592389 Woods 2018 (16) | 1 | rs2830 Woods 2018 (16) |
| Hypoxia inducible factor 1 subunit α (HIFA) | rs11549465 (HIFα 1744 C/T) q Schneider 2009 (19) | rs11549467 (HIFα 1762 A/G) r Schneider 2009 (19) | ||
| Kinase insert domain receptor (KDR) | rs2305948 (VEGFR2 889 A/G) s , rs1870377 (VEGFR2 1416 A/T) t Schneider 2009 (19) | |||
| Nitric oxide synthase 3 (eNOS) | rs2070744 (eNOS-786 T/C) u , rs1799983 (eNOS 894 G/T) v Schneider 2009 (19) | |||
| Solute carrier family 6 member 4 (SLC6A4) (serotonin transporter gene) | 1 | rs11080121; rs2066713; rs40147 Montasser 2015 (27) | 1 | rs140700; rs8076005; rs4251417; rs16965628; rs4404067; rs4238784; rs747107; rs13333066; rs187715; rs36026; rs36024; rs36021; rs3785151; rs36020; rs16955591; rs3785152; rs1814270; rs5564; rs5568; rs1566652; rs5569; rs2242447; rs424605; rs16955708; rs12596924; rs258099; Montasser 2015 (27) |
| Sulfotransferase family 1A member 1 (SULT1A1) | 1 | rs1801030 Rebbeck 2010 (3) | 1 | rs9282861 Rebbeck 2010 (3) |
| sulfotransferase family 1E member 1 (SULT1E1) | – | – | 1 | rs3736599; rs3786599 Rebbeck 2010 (3) |
| Tachykinin receptor 3 | 1 | rs74827081; rs74589515; rs79246187; rs112390256; rs75544266; rs78154848; rs76643670; rs78289784; rs77322567; rs78141901; rs78844131; rs79852843; rs80328778; rs112623956 Crandall 2017 (22) | – | – |
| Vascular endothelial growth factor A (VEGFA) | rs699947 (VEGF-2578 C/A)x, rs2010963 (VEGF-634 G/C)y, rs1570360 (VEGF-1154 G/C)z, rs3025039 (VEGF 936 C/T)aa Schneider 2009 (19) |
a – indicates that no studies fulfill the criteria; studies in boldface indicate additional results revealed by the sensitivity analysis.
b Studies were focused on differences between smokers and nonsmokers with a given genotype
c Reference for corresponding rs number is Naif et al 2019 PMID 29707532; dbsnp link https://www.ncbi.nlm.nih.gov/snp/rs1048943
d Studies were focused on differences between smokers and nonsmokers with a given genotype
e Studies were focused on differences between smokers and nonsmokers with a given genotype
f Reference for corresponding rs number is Candrakova 2018 PMID: 29285838; dbSNP link https://www.ncbi.nlm.nih.gov/snp/rs1056836
g Reference for corresponding rs number is Reding et al 2009 PMID 19383894; dbSNP link https://www.ncbi.nlm.nih.gov/snp/rs1056827
h Reference for corresponding rs number is Martinez-Ramirez 2015 PMID 26123186; dbSNP link https://www.ncbi.nlm.nih.gov/snp/rs1056836
i Reference for corresponding rs number is Butts 2012 PMID 22466345; dbSNP link https://www.ncbi.nlm.nih.gov/snp/rs1056836
j Studies were focused on differences between smokers and nonsmokers with a given genotype
k Reference for corresponding rs number is Mao et al 2010 PMID 20033766; dbSNP link https://www.ncbi.nlm.nih.gov/snp/rs743572
l Reference for corresponding rs number is Mao et al 2010 PMID 20033766; dbSNP link https://www.ncbi.nlm.nih.gov/snp/rs743572
m Reference for corresponding rs number is Hayes et al 2010 PMID 20827267; dbSNP link https://www.ncbi.nlm.nih.gov/snp/rs9340799
n Reference for corresponding rs number is Hayes et al 2010 PMID 20827267; dbsnp link https://www.ncbi.nlm.nih.gov/snp/rs2234693
o Reference for corresponding rs number is Hayes et al 2010 PMID 20827267; dbSNP link https://www.ncbi.nlm.nih.gov/snp/rs9340799
p Reference for corresponding rs number is Hayes et al 2010 PMID 20827267; dbSNP link https://www.ncbi.nlm.nih.gov/snp/rs2234693
q Reference for corresponding rs number is Heino et al 2008 PMID 18980686; dbSNP link https://www.ncbi.nlm.nih.gov/snp/rs11549465
r Reference for corresponding rs number is Heino et al 2008 PMID 18980686; dbSNP link https://www.ncbi.nlm.nih.gov/snp/rs11549467
s Reference for corresponding rs number is Lopes-Aguiar et al 2017 PMID 28665417; dbSNP link https://www.ncbi.nlm.nih.gov/snp/rs2305948
t Reference for corresponding rs number is Lakkireddy et al 2016 PMID 26476544; dbSNP link https://www.ncbi.nlm.nih.gov/snp/rs1870377
u Reference for corresponding rs number is Loo et al 2012 PMID 22594584; dbSNP link: https://www.ncbi.nlm.nih.gov/snp/rs2070744
v Reference for corresponding rs number is Loo et al 2012 PMID 22594584; dbSNP link: https://www.ncbi.nlm.nih.gov/snp/rs1799983
x Reference for corresponding rs number is Schneider et al 2008 PMID 17891484; dbSNP link: https://www.ncbi.nlm.nih.gov/snp/rs699947
y Reference for corresponding rs number is Schneider et al 2008 PMID 17891484; dbSNP link: https://www.ncbi.nlm.nih.gov/snp/rs2010963
z Reference for corresponding rs number is Schneider et al 2008 PMID 17891484; dbSNP link: https://www.ncbi.nlm.nih.gov/snp/rs1570360
aa Reference for corresponding rs number is Schneider et al 2008 PMID 17891484; dbSNP link: https://www.ncbi.nlm.nih.gov/snp/rs3025039