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. 2020 Oct 5;14(5):051303. doi: 10.1063/5.0012185

FIG. 2.

FIG. 2.

Microfluidic-based in vitro models for mimicking host–microbe interactions. (a) Multi-layered microchip with semi-permeable membrane coated with ECM for investigating viral infection in a lung-on-chip.63 (b) A four-layer microfluidic device with integrated TEER electrodes for studying gut–microbiome59 interactions. Reproduced with permission from Shah et al., Nat. Commun. 7, 11535 (2016). Copyright 2016 Author(s), licensed under a Creative Commons Attribution (CC BY) license. (c) Compartmentalized microfluidic device with migrating channels for analyzing neutrophil migration when skin columns were inoculated with Staphylococcus aureus.64 Reproduced with permission from Kim et al., Lab Chip 19(18), 3094–3103 (2019). Copyright 2019 Royal Society of Chemistry.121 (d) Chemotatic channels in microfluidic device for allowing biochemical factors to diffuse into collagen gel and for observing bacterial preference for cancer cells as compared to healthy cells.61 Reproduced with permission from Hong et al., Lab Chip 13(15), 3033–3040. Copyright 2013 Royal Society of Chemistry.