Figure 1. Partial correlations between regional volumes and global neuropathologic scores.

Partial correlations between regional volumes and global neuropathologic scores, controlling for age, sex, and interval between MRI and death. Numbers in blue indicate nonsignificant effects, numbers in red indicate significant effects at a p value < 0.05, uncorrected for multiple comparisons, and numbers in red with an * indicate significant effects at a false discovery rate–corrected p value < 0.05. All volumes are normalized to the individual total intracranial volume. BF = basal forebrain volume according to ref. 4; Braak stages = Braak stages for neurofibrillary pathology; Hip = hippocampal volume according to ref. 22; LB binary = presence of Lewy body pathology (assessed according to dementia with Lewy bodies criteria as brainstem predominant, limbic, neocortical, amygdala predominant), yes/no; Neur. plaques = Consortium to Establish a Registry for Alzheimer’s Disease score for density of neocortical neuritic plaques; Parahip = parahippocampal gyrus from the Hammers atlas²³; TDP binary = presence of TDP-43 pathology (assessed in the following regions: spinal cord, amygdala, hippocampus, entorhinal cortex, neocortical), yes/no; Thal phases = Thal phases for amyloid plaques.