Table 3.

ADMET Profiling for absorption, metabolism and toxicity parameters of identified compounds.

Model	NPACT01552	NPACT01557	NPACT00631
A. Absorption and distribution
Blood-brain barrier	No	No	No
Human intestinal absorption	High	High	High
Caco-2 permeability	Yes	Yes	No
P-glycoprotein inhibitor	Inhibitor	Inhibitor	Non inhibitor
Renal Organic cation transporter	Non inhibitor	Non inhibitor	Non inhibitor
B. Metabolism
CYP450 2C9	Non inhibitor	Non inhibitor	Non inhibitor
CYP450 2D6	Non inhibitor	Non inhibitor	Non inhibitor
CYP450 3A4	Non inhibitor	Non inhibitor	Non inhibitor
CYP450 1A2	Non inhibitor	Non inhibitor	Non inhibitor
CYP450 2C19	Non inhibitor	Non inhibitor	Non inhibitor
C. Toxicity
AMES (mutagenicity)	Non ames toxic	Non ames toxic	Non ames toxic
Carcinogens	Non carcinogens	Non carcinogens	Non carcinogens